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The Sinclair Method

A revolutionary treatment for problem drinking that uses targeted naltrexone therapy, and is clinically-proven to have a 78% success rate



The Sinclair Method (TSM) is a science-based protocol for treating alcohol use disorder. It uses the medication naltrexone in a targeted dose. Over time, most people using this protocol will experience fewer alcohol cravings and less interest in drinking.

The Sinclair Method Explained

Here's a short video clip of Dr David Sinclair explaining his discovery of The Sinclair Method, and how and why it works


According to Dr David Sinclair's research:

  • Addiction to alcohol is a learned behavior inside the brain's neural pathways
  • Over time with repeated drinking, these pathways become stronger, leading to compulsive drinking
  • The Sinclair Method (TSM) treats alcohol addiction where it is learned ‚Äď which is inside the brain
  • For approximately 80% of people, TSM can result in pharmacological extinction of the alcohol addiction. In other words, the alcohol addiction can be reversed
  • The Sinclair Method does not require willpower as it reduces interest in alcohol after several months of treatment
  • Over 90 clinical trials have supported the effectiveness of the Sinclair Method

To read more about the scientific research behind this method, visit here or read the book, The Cure for Alcoholism by Dr Roy Eskapa.


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More About Naltrexone

  • Naltrexone has been¬†approved by the FDA for treatment of alcohol use disorder since 1994.
  • Naltrexone is considered a safe, non-addictive and non-habit-forming medication that has very few interactions or side effects for most people.
  • Following The Sinclair Method, naltrexone works by blocking the endorphin reward¬†from alcohol. It does not make a person sick from alcohol like Antabuse.
  • A prescription is required in most parts of the world for naltrexone.
  • When you enroll in The Alcohol Freedom Program, we'll connect you with a telemedicine physician who will prescribe and monitor your prescription. ūüĎć

How The Sinclair Method Works

According to Dr David Sinclair's research, the Sinclair Method works by dealing with alcohol use disorder on a neurological level. ūü߆¬†Here's how:

Step 1

When a person consumes alcohol ‚Äď it produces a flood of feel-good hormones in the brain, including endorphins. This is why drinking can feel so pleasurable.

Step 2

The feel-good hormones are what drive individuals keep craving, drinking & over-drinking alcohol, & ultimately developing patterns of alcohol use disorder (AUD). 

Step 3

Research has shown that¬†FDA-approved medications like naltrexone can block those feel-good hormones while drinking ‚Äď making the experience slightly less "rewarding."

Step 4

Sinclair's research also showed that when those feel-good hormones are blocked repeatedly over time, most people gradually & naturally experience less interest in alcohol.

Step 5

As someone experiences less interest in alcohol, they are encouraged to make lifestyle & habit changes, & cultivate new coping strategies in order to shift the behaviors associated with over-drinking. 

Step 6

Many people who use The Sinclair Method report that they have the option to drink in moderation & with control; others go alcohol-free in the with greater ease thanks to pharmacological extinction.


Learn more about how our program has helped people just like you sustainably change drinking habits using The Sinclair Method


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Naltrexone Works Best When Combined With Support

According to the Journal of Clinical Psychopharmacology, several studies have shown that naltrexone works best when combined with behavioral support for coping and habit change. That's why we guide and support you through this in the program, at your own pace.

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How Can Naltrexone & The Sinclair Method Help Me Change My Drinking Habits?*


  1. Regained control over alcohol. This means "forgetting" to drink, not being able to finish a drink, or being able to keep alcohol in the house without drinking it.
  2. Cravings for alcohol reduced or eliminated.  This means your mind can feel more "free" as you think about alcohol less often. Many people don't even realize how much they are thinking about alcohol until they go on The Sinclair Method.
  3. Choice of moderation or abstinence. It's up to you to decide what type of role you want alcohol to play in your life. Many people have a goal to drink moderately, and others quit drinking with greater ease through The Sinclair Method.

*Results on The Sinclair Method vary person to person and Thrive does not guaranteed these results, but we do our very best to help you achieve your personal goals! ūü§ó


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"I support The Sinclair Method because all throughout my psychiatric residency training, alcohol treatment was very all or none in regards to AA and abstinence or using medications like Antabuse or Campral, with essentially expected poor outcomes. When I learned about The Sinclair Method, it was a lightbulb moment, and I saw immediate life-changing  responses with my patients. I have been a believer since then, as this has been the only treatment where I have seen consistent and sustained positive results. It is a game-change and a life-saver."

Sulman Aziz Mirza, MD
Triple Board Certified Psychiatrist, LouCouPsych

Access Sinclair Method Success Stories

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Sinclair Method Frequently Asked Questions

Have more questions about The Sinclair Method? Check out our blog post where we answer the most commonly asked questions.

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Since 2018, we have helped hundreds of people gain control over alcohol using The Sinclair Method.

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Learn about the physician-recommended support program for targeted use of naltrexone, commonly referred to as The Sinclair Method