The Sinclair Method

A revolutionary treatment proven to help most people reduce their drinking and regain control


The Sinclair Method (TSM) is a science-based protocol for treating alcohol use disorder. It uses the medication naltrexone in a targeted dose. Over time, most people using TSM experience reduced alcohol cravings, easier alcohol-free days, and greater control when they drink.

What Is the Sinclair Method?

In this video, you'll discover 1. What the Sinclair Method is 2. How it works 3. The timeline for seeing results 4. Who it's ideal for 5. How to get started with the treatment.


What is the Sinclair Method?

  • A science-based treatment designed to help reduce alcohol consumption over time.
  • Requires taking Naltrexone one hour before drinking.

How It Works:

  • Naltrexone blocks some euphoric effects of alcohol, reducing its reward.
  • Over time, the brain unlearns addictive patterns, helping most people regain control.


  • Success rate of around 78%.
  • Typically takes 9 months to a year for full results.

Who is it For?

  • People currently drinking who want to reduce consumption.


Ready to try it for yourself?


How Long Does The Sinclair Method Take to Work?

We often compare the Sinclair Method to a weight loss journey, where gradual, sustainable changes yield the best results.

With TSM, most people reduce their drinking incrementally, typically seeing full results within a year. Even subtle changes are encouraging, as individuals start to feel in control of their drinking again.

Sample drink chart for a Sinclair Method user


How The Sinclair Method Works

According to Dr David Sinclair's research, the Sinclair Method works by dealing with alcohol use disorder on a neurological level. ūü߆¬†Here's how:

Step 1

When consumed, alcohol triggers the release of feel-good hormones in the brain, such as endorphins, leading to a pleasurable sensation

Step 2

Feel-good hormones drive the craving, drinking, and excessive alcohol consumption that leads to the development of alcohol use disorder (AUD)

Step 3

Research indicates that FDA-approved medications like naltrexone can block feel-good hormones during drinking, reducing the overall rewarding experience

Step 4

Sinclair's research revealed that repeated blocking of feel-good hormones over time leads to a natural decline in alcohol interest for most individuals

Step 5

As alcohol interest wanes, individuals are urged to adopt lifestyle changes, develop new coping strategies, and shift behaviors linked to excessive drinking

Step 6

TSM users often share that they can choose moderation or alcohol-free living more easily through this treatment


Learn more about how our program has helped people just like you sustainably change drinking habits using The Sinclair Method


Learn more

More About Naltrexone

  • Naltrexone has been¬†approved by the FDA for treatment of alcohol use disorder since 1994.
  • Naltrexone is considered a safe, non-addictive and non-habit-forming medication that has very few interactions or side effects for most people.
  • Following The Sinclair Method, naltrexone works by blocking the endorphin reward¬†from alcohol. It does not make a person sick from alcohol like Antabuse.
  • A prescription is required in most parts of the world for naltrexone.
  • When you enroll in The Alcohol Freedom Program, we'll connect you with a telemedicine physician who will prescribe and monitor your prescription. ūüĎć

Research Shows Naltrexone Works Best When Combined With Support


Dr. Joseph Volpicelli, leading naltrexone
expert researcher and physician explains the importance of support alongside medication therapy for alcohol use disorder.

And that's why our program delivers personalized¬†guidance to you at your own pace.¬†ūü§ó

How Can Naltrexone & The Sinclair Method Help Me Change My Drinking Habits?*


  1. Regained control over alcohol. This means "forgetting" to drink, not being able to finish a drink, or being able to keep alcohol in the house without drinking it.
  2. Cravings for alcohol reduced or eliminated.  This means your mind can feel more "free" as you think about alcohol less often. Many people don't even realize how much they are thinking about alcohol until they go on The Sinclair Method.
  3. Choice of moderation or abstinence. It's up to you to decide what type of role you want alcohol to play in your life. Many people have a goal to drink moderately, and others quit drinking with greater ease through The Sinclair Method.

*While outcomes may vary, please know that we genuinely care about your success. Our team is here to support you every step of the way, no matter how long it takes.


"I support The Sinclair Method because all throughout my psychiatric residency training, alcohol treatment was very all or none in regards to AA and abstinence or using medications like Antabuse or Campral, with essentially expected poor outcomes. When I learned about The Sinclair Method, it was a lightbulb moment, and I saw immediate life-changing responses with my patients. I have been a believer since then, as this has been the only treatment where I have seen consistent and sustained positive results. It is a game-change and a life-saver."

Sulman Aziz Mirza, MD
Triple Board Certified Psychiatrist, LouCouPsych

Thrive Member Testimonial 


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Sinclair Method Frequently Asked Questions

Have more questions about The Sinclair Method? Check out our blog post where we answer the most commonly asked questions.

Read FAQs
Since 2018, we have helped hundreds of people gain control over alcohol using The Sinclair Method.

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Get Started on The Sinclair Method

Learn about the physician-recommended support program for targeted use of naltrexone, commonly referred to as The Sinclair Method