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The Sinclair Method

A revolutionary treatment for problem drinking that uses targeted naltrexone therapy, and is clinically-proven to have a 78% success rate



The Sinclair Method (TSM) is a science-based protocol for treating alcohol use disorder. It uses the medication naltrexone in a targeted dose. Over time, most people using this protocol will experience fewer alcohol cravings and less interest in drinking.

The Sinclair Method Explained

Here's a short video clip of Dr David Sinclair explaining his discovery of The Sinclair Method, and how and why it works


According to Dr David Sinclair's research:

  • Addiction to alcohol is a learned behavior inside the brain's neural pathways
  • Over time with repeated drinking, these pathways become stronger, leading to compulsive drinking
  • The Sinclair Method (TSM) treats alcohol addiction where it is learned – which is inside the brain
  • For approximately 80% of people, TSM can result in pharmacological extinction of the alcohol addiction. In other words, the alcohol addiction can be reversed
  • The Sinclair Method does not require willpower as it reduces interest in alcohol after several months of treatment
  • Over 90 clinical trials have supported the effectiveness of the Sinclair Method

To read more about the scientific research behind this method, visit here or read the book, The Cure for Alcoholism by Dr Roy Eskapa.


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More About Naltrexone

  • Naltrexone has been approved by the FDA for treatment of alcohol use disorder since 1994.
  • Naltrexone is considered a safe, non-addictive and non-habit-forming medication that has very few interactions or side effects for most people.
  • Following The Sinclair Method, naltrexone works by blocking the endorphin reward from alcohol. It does not make a person sick from alcohol like Antabuse.
  • A prescription is required in most parts of the world for naltrexone.
  • When you enroll in The Alcohol Freedom Program, we'll connect you with a telemedicine physician who will prescribe and monitor your prescription. 👍

Research Shows Naltrexone Works Best When Combined With Support


Dr. Joseph Volpicellileading naltrexone
expert researcher and physician explains the importance of support alongside medication therapy for alcohol use disorder.

And that's why our program delivers personalized guidance to you at your own pace. 🤗

How The Sinclair Method Works

According to Dr David Sinclair's research, the Sinclair Method works by dealing with alcohol use disorder on a neurological level. 🧠 Here's how:

Step 1

When consumed, alcohol triggers the release of feel-good hormones in the brain, such as endorphins, leading to a pleasurable sensation

Step 2

Feel-good hormones drive the craving, drinking, and excessive alcohol consumption that leads to the development of alcohol use disorder (AUD)

Step 3

Research indicates that FDA-approved medications like naltrexone can block feel-good hormones during drinking, reducing the overall rewarding experience

Step 4

Sinclair's research revealed that repeated blocking of feel-good hormones over time leads to a natural decline in alcohol interest for most individuals

Step 5

As alcohol interest wanes, individuals are urged to adopt lifestyle changes, develop new coping strategies, and shift behaviors linked to excessive drinking

Step 6

TSM users often share that they can choose moderation or alcohol-free living more easily through this treatment


Learn more about how our program has helped people just like you sustainably change drinking habits using The Sinclair Method


Learn more

"I support The Sinclair Method because all throughout my psychiatric residency training, alcohol treatment was very all or none in regards to AA and abstinence or using medications like Antabuse or Campral, with essentially expected poor outcomes. When I learned about The Sinclair Method, it was a lightbulb moment, and I saw immediate life-changing responses with my patients. I have been a believer since then, as this has been the only treatment where I have seen consistent and sustained positive results. It is a game-change and a life-saver."

Sulman Aziz Mirza, MD
Triple Board Certified Psychiatrist, LouCouPsych

Thrive Member Testimonial 


How Can Naltrexone & The Sinclair Method Help Me Change My Drinking Habits?*


  1. Regained control over alcohol. This means "forgetting" to drink, not being able to finish a drink, or being able to keep alcohol in the house without drinking it.
  2. Cravings for alcohol reduced or eliminated.  This means your mind can feel more "free" as you think about alcohol less often. Many people don't even realize how much they are thinking about alcohol until they go on The Sinclair Method.
  3. Choice of moderation or abstinence. It's up to you to decide what type of role you want alcohol to play in your life. Many people have a goal to drink moderately, and others quit drinking with greater ease through The Sinclair Method.

*While outcomes may vary, please know that we genuinely care about your success. Our team is here to support you every step of the way, no matter how long it takes.


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Access Sinclair Method Success Stories

Get access to real interviews by people who have overcome problem drinking through naltrexone and The Sinclair Method


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Sinclair Method Frequently Asked Questions

Have more questions about The Sinclair Method? Check out our blog post where we answer the most commonly asked questions.

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Since 2018, we have helped hundreds of people gain control over alcohol using The Sinclair Method.

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Get Started on The Sinclair Method

Learn about the physician-recommended support program for targeted use of naltrexone, commonly referred to as The Sinclair Method