The Sinclair Method — With Support That Makes Change Possible
A science-backed approach using naltrexone, guided inside Thrive’s private online program.
Explore the Thrive ProgramWhat is the Sinclair Method?
The Sinclair Method (TSM) is a proven, science-backed approach to treating alcohol use disorder. It involves naltrexone, a medication taken before drinking to block the release of endorphins triggered by alcohol. Over time, TSM helps retrain the brain, leading to fewer alcohol cravings, more effortless alcohol-free days, and greater control over drinking habits.
Key Benefits of the Sinclair Method
TSM is a powerful solution for those who want to regain control and moderate their drinking, offering a stress-free, sustainable approach without the pressure to quit entirely.
How Thrive Helps You Succeed with the Sinclair Method
The Sinclair Method is powerful — but success comes from applying it consistently in real life. Inside Thrive, you receive structured guidance and ongoing support every step of the way.
Private Guided TSM Program
A fully online program designed specifically for the Sinclair Method — helping you understand the process, stay consistent, and navigate real-life challenges at your own pace.
Naltrexone Physician Referral
Need a prescription? Members receive referrals to experienced physicians familiar with the Sinclair Method (consult and medication billed separately).
Coaching & Personalized Guidance
Work with certified coaches who have personally used TSM themselves. Choose group coaching, private sessions, or deeper one-on-one support.
Weekly Support & Workshops
Live calls and focused workshops provide encouragement, troubleshooting, and guidance throughout every phase of change — or simply listen and learn when you need it.
Step-by-Step Learning Library
Clear, structured lessons that show you what to expect, how habits change, and how to move through the Sinclair Method with confidence.
Private Member Community
A judgment-free space to connect with others using TSM — with coaches actively engaged so you’re never navigating treatment alone.
Is the Sinclair Method Right for Me?
This 15-minute video provides a clear overview of the treatment, detailing who can benefit from it and who it may not be suitable for.
Dr. Sinclair’s Discovery: A Breakthrough Way to Treat Alcoholism
- 🧠 According to Dr. David Sinclair, alcohol addiction is a learned behavior in the brain.
- 🔁 Repeated drinking strengthens neural pathways, leading to compulsive use.
- 🎯 The Sinclair Method (TSM) targets addiction where it’s learned – inside the brain.
- ✅ TSM can reverse addiction in about 80% of people through pharmacological extinction.
- 💪 It doesn’t rely on willpower – cravings naturally fade over time.
How the Sinclair Method Works
According to Dr David Sinclair's research, TSM the power of naltrexone, a medication that blocks the release of endorphins—the chemical rewards in the brain triggered by drinking alcohol.
Endorphin Blocking
TSM uses naltrexone, a medication that blocks the release of endorphins—chemical rewards in the brain triggered by drinking alcohol.
Interrupting the Cycle
Taking naltrexone an hour before drinking prevents these endorphins from creating the pleasurable "buzz" that reinforces habitual drinking.
Rewiring the Brain
Over time, this process helps your brain “unlearn” the connection between alcohol and pleasure, gradually reducing cravings and the compulsion to drink.
Learn more about how our program has helped people just like you sustainably change drinking habits using the Sinclair Method
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How to Do the Sinclair Method in Real Life
The Sinclair Method follows a clear protocol — but lasting change happens as people learn how to use it consistently in everyday life.
Take Naltrexone Before Drinking 💊
Naltrexone is taken approximately one hour before alcohol consumption so the medication can block alcohol’s endorphin reward in the brain.
Drink While Protected🍷
When alcohol is consumed with naltrexone active, the brain no longer receives the same chemical reinforcement. Over repeated sessions, this weakens the learned connection between alcohol and reward.
Gradual Change Over Time 💪
With consistent use, many people notice cravings decrease and drinking becomes easier to reduce — a process known as pharmacological extinction.
Where Guidance Makes the Difference on the Sinclair Method
Understanding the protocol is only one part of the process. Real progress happens as people learn how to stay consistent while habits, routines, and motivation naturally shift over time.
Successful change often involves learning how to:
Structured guidance helps translate a research-backed method into lasting change in everyday life.
Meeting the Medication Halfway
1. 💊 Take the Medication Consistently
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Always take naltrexone as prescribed before drinking.
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Establish a routine to help the medication work effectively.
2. 📉 Track Your Progress
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Keep a drink log to notice patterns and progress over time.
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Reflect on changes in your cravings and drinking habits.
3. 💆 Explore New Coping Strategies
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Find activities that help you unwind or bring joy without relying on alcohol.
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Start small by incorporating one new healthy habit at a time.
4. 📆 Be Patient and Stay Committed
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TSM is a gradual process, not a quick fix.
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Celebrate small wins and don’t let setbacks discourage you.
By partnering with the medication in this way, you can make real progress and regain control over your relationship with alcohol.
At Thrive, we specialize in helping you with this. 😎
Sinclair Method FAQs
What else do I do besides take the medication?
How long does it take the Sinclair Method to work?
How do I get started on the Sinclair Method?
How does the Sinclair Method compare to traditional abstinence-based approaches?
What are the side effects of naltrexone?
What is naltrexone?
What does it feel like to drink alcohol on naltrexone?
Daily naltrexone vs the Sinclair Method: what's the difference?
Is a prescription required for naltrexone or is it over-the-counter?
What happens if I stop taking naltrexone?
Sinclair Method Success Stories
Discover inspiring stories from real people who've struggled with alcohol issues and overcome them with this powerful approach
Ready to try it for yourself?
"I support the Sinclair Method because all throughout my psychiatric residency training, alcohol treatment was very all or none in regards to AA and abstinence or using medications like Antabuse or Campral, with essentially expected poor outcomes. When I learned about the Sinclair Method, it was a lightbulb moment, and I saw immediate life-changing responses with my patients. I have been a believer since then, as this has been the only treatment where I have seen consistent and sustained positive results. It is a game-change and a life-saver."
Sulman Aziz Mirza, MD
Triple Board Certified Psychiatrist, LouCouPsych
Since 2018, we have helped thousands of people gain control over alcohol using the Sinclair Method.
Will you be next?
